Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Multifunctional MIL-S─CUR@FC nanoparticles: a targeted theranostic agent for magnetic resonance imaging and tumor targeted delivery of curcumin

Introduction: Noninvasive magnetic resonance imaging (MRI) and targeted drug delivery systems, usually referred to as theranostic agents, are being developed to enable detection, site-specific treatment, and long-term monitoring.   Materials and Methods: To elucidate the effects of coating on cellular uptake and biodistribution of n...

متن کامل

Perfusion Changes following EGFR Targeted Hollow Gold-Nanoshell Mediated Heating of Tumors

Introduction Drug delivery into tumors has been variable due to factors like increased interstitial pressure, poor vasculature and tumor heterogeneity. This has hampered the clinical translation of many drugs which were successful in initial in vitro experiments. To overcome this obstacle, researchers have used hyperthermia protocols to improve tumor drug uptake with good results. But lack of r...

متن کامل

Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis.

Clinical diagnosis of cancers using magnetic resonance imaging (MRI) is highly dependent on contrast agents, especially for brain tumors which contain blood-brain barrier (BBB) at the early stage. However, currently mostly used low molecular weight contrast agents such as Gd-DTPA suffer from rapid renal clearance, non-specificity, and low contrast efficiency. The aim of this paper is to investi...

متن کامل

Building a Better Magnetic Resonance Imaging Contrast Agent Using Macromolecular Architecture

In vivo imaging enables us to peer deeply within living subjects and is producing tremendous opportunities both for the study of cancer biology and clinical diagnostics. Rapid advances in fluorescent imaging, magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), and ultrasound imaging promise to translate the insights from basic science at the single-ce...

متن کامل

Sonophore labeled RGD: a targeted contrast agent for optoacoustic imaging

Optoacoustic imaging is a rapidly expanding field for the diagnosis, characterization, and treatment evaluation of cancer. However, the availability of tumor specific exogenous contrast agents is still limited. Here, we report on a small targeted contrast agent for optoacoustic imaging using a black hole quencher® (BHQ) dye. The sonophore BHQ-1 exhibited strong, concentration-dependent, optoaco...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biomaterials

سال: 2010

ISSN: 0142-9612

DOI: 10.1016/j.biomaterials.2010.05.001